James S. Clegg, Ph.D. Professor of Molecular & Cellular Biology Education and Training: B.S. Pennsylvania State University, 1955-58 Ph.D. The Johns Hopkins University, 1958-61 Phone: (707) 875-2010 Email: Fax: (707) 875-2009

Research Interests:

Biochemical and biophysical adaptations to environmental extremes; stress proteins and molecular chaperones in invertebrates; organization of enzymes and metabolic activity in the aqueous compartments of cells.

Selected Publications:

Pollack, G.H. and J.S. Clegg. 2008. Unexpeccted linkage between unstirred layers, exclusion zones and water. In: Phase Transitions in Biology (G.H. Pollack and W.C. Chin, editors) Springer, in press

Beladjal, L., J. Mertens and J.S. Clegg. 2008. Biochemical and biophysical aspects
of the tolerance of anhydrobiotic crustacean embryos to very high temperatures. J.
Thermal Biol. in press

Clegg, J.S. 2007. Protein stability in Artemia embryos during prolonged anoxia. Biol.
Bull.212:74-81

Clegg, J.S. and V.C. Campagna. 2006. Comparisons of stress proteins and soluble
carbohydrate in encysted embryos of Artemia franciscana and two species of
Parartemia. Comp. Biochem. Physiol. B. 145:119-125

Clegg, J.S. 2005. Desiccation tolerance in the animal extremophile, Artemia. Integrative
Comp. Biol. 45:715-724. (SICB symposium paper)

Qiu, Z., R.I. Viner, T.H. MacRae, J.K. Willsie and J.S. Clegg. 2004. A small heat shock
protein from Artemia franciscana is phosphorylated at serine 50. Biochim. Biophys. Acta 1700:75-83.

Warner, A.H., R.T. Brunet, T.H. MacRae and J.S. Clegg. 2004. Artemin is an RNA-binding protein with high thermal stability and potential RNA chaperone activity. Arch. Biochem. Biophys. 424:189-200.

Tanguay, J.A., R.C. Reyes and J.S. Clegg. 2004. Habitat diversity and adaptation to environmental stress in encysted embryos of the crustacean Artemia. J. Biosciences 29:489-501 (IUBS symposium paper).

Collins, C.H. and J.S. Clegg. 2004. A small heat shock protein, p26, from the crustacean Artemia protects mammalian cells (Cos-1) against oxidative damage. Cell Biol. Intern. 28:449-455.

Chen, T., R. Amons, J.S. Clegg, A.H. Warner and T.M. MacRae. 2003. Molecular
characterization of artemin and ferritin from Artemia franciscana. Eur. J. Biochem. 270:137-145.

Clegg, J.S. and C.N.A. Trotman. 2002. Physiological and biochemical aspects of Artemia ecology. pp 129-170. In: Artemia: Basic and Applied Biology. (Th. J. Abatzopoulos, J.A. Beardmore, J.S. Clegg and P. Sorgeloos, eds.) Kluwar Academic Publishers, Dordrecht, The Netherlands.

Willsie, J.K. and J.S. Clegg. 2002. The small heat shock protein p26 associates with nuclear lamins and hsp70 in nuclei and nuclear matrix fractions from stressed cells. J. Cell. Biochem. 84:601-614.

Clegg, J.S., N.V. Hoa and P. Sorgeloos. 2001. Thermal tolerance and heat shock proteins in encysted embryos of Artemia from widely different thermal habitats. Hydrobiologia 466:221-229.

Warner, A.H. and J.S. Clegg. 2001. Diguanosine nucleotide metabolism and the survival of Artemia embryos during years of continuous anoxia. Eur. J. Biochem. 268:1568-1576.

Viner, R.I. and J.S. Clegg. 2001. Influence of trehalose on the molecular chaperone p26, a small heat-shock alpha-crystallin protein. Cell Stress & Chaperones 6:126-135

Clegg, J.S. 2001. Cryptobiosis - a peculiar state of biological organization. Comp. Biochem. Physiol. B. 128:613-624. (review)

Willsie, J.W. and J.S. Clegg. 2001. Nuclear p26, a small heat shock / alpha-crystallin protein, and its relationship to stress resistance in Artemia embryos. J. Exp. Biol. 204: 2339-2350.

Clegg, J.S. 2000. Water in Living Cells: the Elemental Fluid Upon Which All Life Depends (in German). In: Water: an International Congress. (B. Busch, editor) pp89-96. Kunst- und Ausstellungshalle der Bundesrepublik Deutschland publication.

Frankenberg, M.M., S.A. Jackson and J.S. Clegg. 2000. The heat shock response of adult Artemia franciscana. J. Thermal Biol. 25:481-490.

Clegg, J.S., S.A. Jackson, N.V. Hoa and P. Sorgeloos. 2000. Thermal resistance, developmental rate and heat shock proteins in Artemia franciscana from San Francisco Bay and southern Vietnam. J. Exp. Mar. Biol. Ecol. 252:85-96.

Clegg, J.S., S.A. Jackson and V.I. Popov. 2000. Long-term anoxia in encysted embryos of the crustacean, Artemia franciscana: viability, ultrastructure and stress proteins. Cell & Tissue Res. 301:433-446.

Clegg, J.S., J.K. Willsie and S.A. Jackson. 1999. Adaptive significance of a small heat shock / alpha-crystallin protein (p26) in encysted embryos of the brine shrimp, Artemia franciscana. Amer. Zool. 39:836-847. (symposium chapter)

Crowe, J.H., J.S. Clegg and L.M. Crowe. 1998. Anhydrobiosis: the water replacement hypothesis. In: The Roles of Water in Foods, pp. 440-455. (D. S. Reid, ed.) Chapman & Hall, NY. (symposium chapter)

Clegg, J.S., K.R. Uhlinger, S.A. Jackson, G.N. Cherr, E. Rifkin and C.S. Friedman. 1998. Induced thermotolerance and the heat shock protein-70 family in the Pacific oyster, Crassostrea gigas. Molec. Mar. Biol. & Biotech. 7:21-30.

Clegg, J.S. and S.A. Jackson. 1998. The metabolic status of quiescent and diapause embryos of Artemia franciscana. Arch. Hydrobiol. 52:425-439 (symposium chapter).

Clegg, J.S. and S.A. Jackson. 1998. Significance of cyst fragments of Artemia sp. recovered from a 27,000 year old core taken under the Great Salt Lake, Utah, USA. Intern. J. Salt Lake Res. 6:207-216..

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